BDBM50010598 1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten-10-yl)-piperazine::CHEMBL91310

SMILES CN1CCN(CC1)C1=Cc2ccccc2C(=C)c2ccccc12

InChI Key InChIKey=NBFZVLQBKCNVGZ-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50010598   

TargetD(1A) dopamine receptor(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataKi:  4.70nMAssay Description:Affinity of the compound was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataKi:  11nMAssay Description:Affinity was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataKi:  18nMAssay Description:Affinity of the compound was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C recept...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataKi:  31nMAssay Description:Affinity was evaluated by inhibition of [3H]-GR-65,630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataKi:  47nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataKi:  57nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataIC50:  150nMAssay Description:Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]QNB as radioligand in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataIC50:  21nMAssay Description:Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50010598(1-Methyl-4-(5-methylene-5H-dibenzo[a,d]cyclohepten...)
Affinity DataIC50:  305nMAssay Description:Binding affinity for Dopamine receptor D2 using [3H]-spiperone in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed