BDBM50011502 CHEMBL3261926

SMILES NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N

InChI Key InChIKey=NNUFRZJZOXVZIT-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50011502   

TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human cathepsin C using H-Gly-Arg-AMC as substrate preincubated for 30 mins before substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of cathepsin C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 5nMAssay Description:Inhibition of cathepsin C in human THP1 cells assessed as inhibition of H-Gly-Phe-AFC cleavage by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 5nMAssay Description:Inhibition of cellular cathepsin C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of DPP1 in human U937 cells using Gly-Phe-AFC as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed
TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin L (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed