BDBM50012648 CHEMBL3261057

SMILES Cc1cc(on1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F

InChI Key InChIKey=APXCHRRPLFZFMP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50012648   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM50012648(CHEMBL3261057)
Affinity DataIC50: 59nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012648(CHEMBL3261057)
Affinity DataIC50: 4.55E+3nMAssay Description:Inhibition of BACE2 (unknown origin) using Biotin-KEISEISYEVEFR-C as substrate after 3 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012648(CHEMBL3261057)
Affinity DataIC50: 4.55E+3nMpH: 4.5 T: 2°CAssay Description:This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent