BDBM50014678 CHEMBL104866::i4-Hydroxy-6-{2-[2-(3-methoxy-phenyl)-5-methyl-pyrrol-1-yl]-ethyl}-tetrahydro-pyran-2-one

SMILES COc1cccc(c1)-c1ccc(C)n1CC[C@@H]1C[C@@H](O)CC(=O)O1

InChI Key InChIKey=ZUJYBBIDWOTFNW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50014678   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014678(CHEMBL104866 | i4-Hydroxy-6-{2-[2-(3-methoxy-pheny...)
Affinity DataIC50: 2.50E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014678(CHEMBL104866 | i4-Hydroxy-6-{2-[2-(3-methoxy-pheny...)
Affinity DataIC50: 2.51E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014678(CHEMBL104866 | i4-Hydroxy-6-{2-[2-(3-methoxy-pheny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014678(CHEMBL104866 | i4-Hydroxy-6-{2-[2-(3-methoxy-pheny...)
Affinity DataIC50: 1.10E+4nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed