BDBM50014686 6-{2-[2-tert-Butyl-5-(4-fluoro-phenyl)-pyrrol-1-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one::CHEMBL319870

SMILES CC(C)(C)c1ccc(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1

InChI Key InChIKey=PMSBINLIZBHCDF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50014686   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014686(CHEMBL319870 | 6-{2-[2-tert-Butyl-5-(4-fluoro-phen...)
Affinity DataIC50: 1.59E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014686(CHEMBL319870 | 6-{2-[2-tert-Butyl-5-(4-fluoro-phen...)
Affinity DataIC50: 1.60E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014686(CHEMBL319870 | 6-{2-[2-tert-Butyl-5-(4-fluoro-phen...)
Affinity DataIC50: 1.80E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50014686(CHEMBL319870 | 6-{2-[2-tert-Butyl-5-(4-fluoro-phen...)
Affinity DataIC50: 2.00E+3nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed