BDBM50014983 1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-thione::CHEMBL278068

SMILES Fc1cc(F)cc(Cn2cc[nH]c2=S)c1

InChI Key InChIKey=WPMVQUHUCQAOBU-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50014983   

TargetDopamine beta-hydroxylase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataKi:  41nMpH: 4.5Assay Description:Binding affinity towards Dopamine beta hydroxylase using tyramine substrate at pH 4.5 in the absence of fumarateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 1.1-1.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Human)
Molecular Simulations

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of dopamine beta hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.0-1.9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Human)
Molecular Simulations

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDopamine beta-hydroxylase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50014983(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against bovine adrenal dopamine beta-hydroxylase(DBH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed