BDBM50017211 CHEMBL3287695::US10099993, Compound 44

SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O

InChI Key InChIKey=XJICBRVIAXTUNH-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50017211   

TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  148nMAssay Description:Agonist activity at rat mGluR2 receptor expressed in HEK293 cells assessed as thallium flux incubated for 2.5 mins prior to thallium buffer addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 3(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  1.77E+3nMAssay Description:Positive allosteric modulation of rat mGluR3 receptor expressed in TREx293 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  12nMAssay Description:Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 3(Human)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  614nMMore data for this Ligand-Target Pair
In DepthDetails US Patent


TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  40nMAssay Description:Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  40nMpH: 7.3 T: 25°CAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetMetabotropic glutamate receptor 3(Rat)
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017211(CHEMBL3287695 | US10099993, Compound 44)
Affinity DataEC50:  614nMAssay Description:Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed