BDBM50018790 17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-diepoxy-6,6'-(imino)[7,7'-bimorphinan]-3,3',14,14'-tetrol

SMILES CN1CC[C@@]23[C@H]4Oc5c2c(CC1[C@]3(O)Cc1c4[nH]c2[C@@H]3Oc4c6c(C[C@H]7N(C)CC[C@@]36[C@@]7(O)Cc12)ccc4O)ccc5O

InChI Key InChIKey=ASOVJVGZJDVADR-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50018790   

TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018790(17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-d...)
Affinity DataKi:  21.7nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against wild-type Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018790(17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-d...)
Affinity DataKi:  41.7nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against K303E Opioid receptor mu 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018790(17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-d...)
Affinity DataIC50: 170nMAssay Description:Agonistic activity in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018790(17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-d...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against E297A mutant Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018790(17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-d...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against E297K mutant Opioid receptor kappa 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50018790(17,17'-Dimethyl-6,6',7,7'-tetradehydro-4,5:4',5'-d...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity using [3H]diprenorphine as the radioligand against wild-type Opioid receptor mu 1 in COS-7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed