BindingDB BDBM50025159 CHEMBL3337869

BDBM50025159 CHEMBL3337869

SMILES COc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1

InChI Key InChIKey=AARSEFXVCWMMKV-UHFFFAOYSA-N

Data 39 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50025159

Interstitial collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP1 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Stromelysin-1(Human)
Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-3 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Stromelysin-1(Human)
Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP3 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrilysin(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP7 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Neutrophil collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 1.10E+3nMAssay Description:Inhibition of human recombinant MMP8 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrix metalloproteinase-9(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP9 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Stromelysin-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 3.40E+3nMAssay Description:Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Matrix metalloproteinase-14(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP14 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Details Article PubMed

Disintegrin and metalloproteinase domain-containing protein 17(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant TACE using Cy3-PLAQAV(Cy5QL-2,3-diaminopropionic acid)-RSSSR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Collagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 12nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

Disintegrin and metalloproteinase domain-containing protein 17(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant TACE using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSRNH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Matrix metalloproteinase-14(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant GST-tagged MMP14 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Details Article PubMed

Stromelysin-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 3.40E+3nMAssay Description:Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrix metalloproteinase-9(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP9 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Neutrophil collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 1.10E+3nMAssay Description:Inhibition of human recombinant MMP8 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrilysin(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP7 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Stromelysin-1(Human)
Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 300nMAssay Description:Inhibition of human recombinant MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Interstitial collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of human recombinant MMP1 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Collagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 12nMAssay Description:Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)

Stromelysin-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 3.40E+3nMAssay Description:Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Interstitial collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human AMPA-activated MMP1 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 300nMAssay Description:Inhibition of recombinant human AMPA-activated MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Collagenase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 5.60nMAssay Description:Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed PDB

3D Structure (crystal)

Neutrophil collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 1.10E+3nMAssay Description:Inhibition of recombinant human AMPA-activated MMP8 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrilysin(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human AMPA-activated MMP7 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Disintegrin and metalloproteinase domain-containing protein 17(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human TACE using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSR-NH2 as substrate measured after 40 mins by spectrofluor...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Matrix metalloproteinase-9(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human AMPA-activated MMP9 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrix metalloproteinase-14(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged MMP14 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Details Article PubMed

Stromelysin-1(Human)
Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human AMPA-activated MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 300nMAssay Description:Inhibition of APMA-activated recombinant human MMP-2 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Neutrophil collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 1.10E+3nMAssay Description:Inhibition of APMA-activated recombinant human MMP-8 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Stromelysin-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 3.40E+3nMAssay Description:Inhibition of APMA-activated recombinant human MMP-10 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Interstitial collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-1 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Matrilysin(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-7 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrix metalloproteinase-9(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-9 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

Matrix metalloproteinase-14(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human GST-tagged MMP-14 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofl...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Details Article PubMed

Disintegrin and metalloproteinase domain-containing protein 17(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: >1.00E+4nMAssay Description:Inhibition of TACE (unknown origin) using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSR-NH2 peptide as substrate measured after 40 mins by spect...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed

72 kDa type IV collagenase(Human)
Takeda Pharmaceutical

Curated by ChEMBL

BDBM50025159(CHEMBL3337869)

IC50: 300nMAssay Description:Inhibition of human recombinant MMP2 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article PubMed