BDBM50028033 CHEMBL3338837::US11458138, Example 312
SMILES CC(C)(N)CNc1nc(nc2cnccc12)-c1ccncc1
InChI Key InChIKey=KSKYRXFKNPXFGI-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50028033
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of ROCK-1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant ROCK-2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:The LATS1 biochemical Caliper assay was performed as following.Human LATS1 kinase domain protein was purchased from Carnabio (catalogue number 01-123...More data for this Ligand-Target Pair
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human recombinant PKC-theta after 60 mins by 33P-ATP incorporation assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Novartis Horsham Research Centre
Curated by ChEMBL
Novartis Horsham Research Centre
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant PKN-2 using AKRRRLSSLRA as substrate after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair