BDBM50030589 N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-oxo-5-p-tolyl-7,8-dihydro-1,7-naphthyridine-6-carboxamide

SMILES CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)c1c(-c2ccc(C)cc2)c2cccnc2c(=O)n1C

InChI Key InChIKey=GIAQQXUCTFYCHO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50030589   

TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 0.240nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 0.240nMAssay Description:Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 0.340nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 0.340nMAssay Description:Antagonist activity at NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 4.20nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50030589(N-(3,5-bis(trifluoromethyl)benzyl)-N,7-dimethyl-8-...)
Affinity DataIC50: 4.20nMAssay Description:Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed