BDBM50033797 (R)-4-Ethyl-4-hydroxy-7-[5-methyl-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-1,4,7,8-tetrahydro-pyrano[3,4-f]indolizine-3,6,10-trione::CHEMBL366675

SMILES CC[C@]1(O)C(=O)OCc2c1cc1C(=O)\C(Cn1c2=O)=C1\C(=O)Nc2ccc(C)cc12

InChI Key InChIKey=OTJCXQYCTIYIPM-YAECTWJJSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50033797   

TargetDNA topoisomerase 1(Human)
Glaxo Research Institute

Curated by ChEMBL
LigandPNGBDBM50033797((R)-4-Ethyl-4-hydroxy-7-[5-methyl-2-oxo-1,2-dihydr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of bovine topoisomerase I, using cleavable complex assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed