BDBM50038261 2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one::CHEMBL340269

SMILES CCCN1C=CC(C)=C2C(=O)NC(N)N=C12

InChI Key InChIKey=YWSKAQWSPONVPP-UHFFFAOYSA-N

Data  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50038261   

TargetDihydrofolate reductase(Gallus gallus (Chicken))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  5.10E+3nMAssay Description:Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with chicken dihydrofolate reductase using equations 11...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  1.20E+3nMpH: 6.6Assay Description:Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  0.5nMAssay Description:Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with chicken dihydrofolate reductase using equation 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  5.30E+3nMAssay Description:Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with chicken dihydrofolate reductase using equation 16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  7.50E+3nMpH: 6.6Assay Description:Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  2.40E+3nMAssay Description:Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with chicken dihydrofolate reductaseusing equations 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  7.10E+3nMpH: 6.6Assay Description:Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  0.600nMAssay Description:Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with chicken dihydrofolate reductase using equation 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  5.50E+3nMpH: 6.6Assay Description:Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Gallus gallus (Chicken))
University of Sydney

Curated by ChEMBL
LigandPNGBDBM50038261(2-Amino-5-methyl-8-propyl-2,8-dihydro-3H-pyrido[2,...)
Affinity DataKd:  6.90E+3nMAssay Description:Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with chicken dihydrofolate reductase using equation 11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed