BDBM50039811 4-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one; hydrochloride::CHEMBL543377

SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1cccc2OCCOc12

InChI Key InChIKey=QHORYEWITOZOQE-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50039811   

Target5-hydroxytryptamine receptor 1A(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50039811(4-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50039811(4-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50039811(4-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Affinity DataEC50:  5.20nMAssay Description:Potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50039811(4-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Affinity DataEC50:  7.40nMAssay Description:Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells (experiment 2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed