BDBM50040587 (R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl)-2-[(S)-3-methyl-1-(2-pyridin-3-yl-pyrrolidine-1-carbonyl)-butylamino]-butyric acid::CHEMBL158622

SMILES CC(C)C[C@H](N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O)C(=O)N1CCCC1c1cccnc1

InChI Key InChIKey=GSCAICSUTUHIKD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50040587   

TargetMatrix metalloproteinase-9(Human)
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040587((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataIC50: 70nMAssay Description:Activity against human gelatinase (MMP-9).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040587((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataIC50: 164nMAssay Description:Activity against human collagenase (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040587((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataIC50: 164nMAssay Description:Activity against human collagenase (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040587((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataIC50: 4.08E+3nMAssay Description:Activity against human stromelysin (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Glaxo Inc. Research Institute

Curated by ChEMBL
LigandPNGBDBM50040587((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Affinity DataIC50: 4.08E+3nMAssay Description:Activity against human stromelysin (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed