BDBM50040790 CHEMBL3353197::US10227340, Example 27::US9242975, 27

SMILES CNC(=O)c1nc(sc1C)-c1cnc(Nc2ccc3ncsc3c2)cc1NC(C)C

InChI Key InChIKey=KOHZPUBPIPEQDV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50040790   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50040790(CHEMBL3353197 | US10227340, Example 27 | US9242975...)
Affinity DataIC50:  1.80nMpH: 7.2 T: 25°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substrates...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50040790(CHEMBL3353197 | US10227340, Example 27 | US9242975...)
Affinity DataIC50:  1.80nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50040790(CHEMBL3353197 | US10227340, Example 27 | US9242975...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of IRAK4 (unknown origin) using fluoresceinated peptide and ATP after 60 mins by by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed