BDBM50040798 CHEMBL3353190::US10023562, Example 12::US10544133, Example 12::US9657009, 12

SMILES CC(C)Nc1cc(Nc2ncc(cc2Cl)C#N)ncc1C(=O)NC[C@@H](F)C(C)(C)O

InChI Key InChIKey=QMDRRQIGSMLIQE-MRXNPFEDSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50040798   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040798(CHEMBL3353190 | US10023562, Example 12 | US1054413...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of IRAK4 (unknown origin) using fluoresceinated peptide and ATP after 60 mins by by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040798(CHEMBL3353190 | US10023562, Example 12 | US1054413...)
Affinity DataIC50:  1.90nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040798(CHEMBL3353190 | US10023562, Example 12 | US1054413...)
Affinity DataIC50:  1.90nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040798(CHEMBL3353190 | US10023562, Example 12 | US1054413...)
Affinity DataIC50:  1.90nMpH: 7.2 T: 25°CAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent