BDBM50042943 CHEMBL3355008::US9789100, Example 18

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(Cl)c(Cl)c2)c(F)c1

InChI Key InChIKey=UHEIXBWQHRWKCW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50042943   

LigandPNGBDBM50042943(CHEMBL3355008 | US9789100, Example 18)
Affinity DataIC50: 300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50042943(CHEMBL3355008 | US9789100, Example 18)
Affinity DataIC50: 500nMAssay Description:Inhibition of RET kinase-mediated proliferative activity against human TT cells by cell-based proliferation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50042943(CHEMBL3355008 | US9789100, Example 18)
Affinity DataIC50: 500nMAssay Description:Inhibition of human RET kinase in TT cells by TRET Kinase cell-based mechanistic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50042943(CHEMBL3355008 | US9789100, Example 18)
Affinity DataIC50: 5.25E+3nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandPNGBDBM50042943(CHEMBL3355008 | US9789100, Example 18)
Affinity DataIC50: 5.25E+3nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent