BDBM50042986 (E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone::1-(4-Hydroxy-phenyl)-3-phenyl-propenone::1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one::CHEMBL276473

SMILES Oc1ccc(cc1)C(=O)\C=C\c1ccccc1

InChI Key InChIKey=UAHGNXFYLAJDIN-IZZDOVSWSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50042986   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  2.30E+5nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAldehyde dehydrogenase, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcetylcholinesterase(Human)
Hu'Nan University

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 25 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCholinesterase(Human)
Hu'Nan University

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate incubated for 25 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] A(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MAOA using p-tyramine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] B(Human)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  182nMAssay Description:Inhibition of recombinant human MAOB using benzylamine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Rat)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  5.75E+4nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTissue factor(Human)TBA
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagula...More data for this Ligand-Target Pair
In DepthDetails Article

TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetChaperonin GroEL(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCo-chaperonin GroES(Escherichia coli)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThiosulfate sulfurtransferase(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042986((E)-1-(4-Hydroxy-phenyl)-3-phenyl-propenone | 1-(4...)
Affinity DataIC50:  2.30E+5nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article