BDBM50044148 CHEMBL3314012

SMILES Cc1ccc(NC(=O)C[C@H](CCC(O)=O)c2noc([C@@H]3C[C@H](CC(C)(C)C)C3)c2C2CC2)c(Cl)c1

InChI Key InChIKey=YWTJAGLMNTUIMB-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50044148   

TargetNuclear receptor ROR-gamma(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataEC50:  13nMAssay Description:Inhibition of GAL4 DNA-binding domain fused RORgamma (unknown origin) transfected in CHO-K1 cells incubated for 2 days by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at human RoRc-LBD expressed in CHO cells assessed as transcriptional activity by GAL4 reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human dopamine D1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5-HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5-HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistamine H2 receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ovine cox-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAcetylcholinesterase(Electric eel)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Electric eel AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 5-HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat adrenergic alpha1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBeta-3 adrenergic receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human adrenergic beta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBeta-2 adrenergic receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetBeta-1 adrenergic receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human adrenergic beta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat adrenergic alpha2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistamine H1 receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCannabinoid receptor 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50044148(CHEMBL3314012)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat L-type Ca2+ channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed