BDBM50045643 3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-3-thia-1-aza-acenaphthylen-2-yl]-2,2-dimethyl-propionic acid::3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-2,2-dimethyl-propionic acid::CHEMBL50170

SMILES CC1Cc2c(OCc3ccc4ccccc4n3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)C(O)=O)c(S1)c23

InChI Key InChIKey=BPNVEWHXKSVOQN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50045643   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50045643(3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylme...)
Affinity DataIC50: 3nMAssay Description:Tested for inhibition of 5-HPETE production by human 5-LOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045643(3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylme...)
Affinity DataIC50: 19nMAssay Description:Compound was tested for its binding activity towards 5-lipoxygenase activating protein (FLAP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50045643(3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylme...)
Affinity DataIC50: 19nMAssay Description:Tested for inhibition of leukotriene biosynthesis by binding to 5-lipoxygenase activating proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045643(3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylme...)
Affinity DataIC50: 300nMAssay Description:Compound was tested for its inhibitory activity against 5-lipoxygenase in rat.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

LigandPNGBDBM50045643(3-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylme...)
Affinity DataIC50: 600nMAssay Description:In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed