BDBM50046903 5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]thiadiazol-2-one::5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,3,4]thiadiazol-2-ol::CHEMBL16827

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1n[nH]c(=O)s1

InChI Key InChIKey=WWZRRRDQLCSEED-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50046903   

TargetProstaglandin G/H synthase 2(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046903(5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]t...)
Affinity DataIC50: 240nMAssay Description:IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046903(5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]t...)
Affinity DataIC50: 4.10E+3nMAssay Description:IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046903(5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]t...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of 5-lipoxygenase measured by the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046903(5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]t...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50046903(5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3H-[1,3,4]t...)
Affinity DataIC50: 2.00E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed