BDBM50047700 CHEMBL3314850

SMILES Clc1ccnc(c1)C(=O)Nc1cncc(Oc2cncnc2)n1

InChI Key InChIKey=UEUUWJVQGWZIJY-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50047700   

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGlu5 expressed in HEK293A cells after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 62nMAssay Description:Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 63nMAssay Description:Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 85nMAssay Description:Negative allosteric modulator activity at human mGlu5 assessed as reduction in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP1A2 in pooled human liver microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in pooled human liver microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in pooled human liver microsomes in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed