BDBM50047704 2-Fluoro-benzoic acid 1,2,3-trimethoxy-9-methylsulfanyl-8-oxo-5,8-dihydro-6H-cyclohepta[a]naphthalen-6-ylmethyl ester::CHEMBL291198

SMILES COc1cc2C[C@H](COC(=O)c3ccccc3F)c3cc(=O)c(SC)ccc3-c2c(OC)c1OC

InChI Key InChIKey=JLXNLLDVVNZOMT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50047704   

TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50047704(2-Fluoro-benzoic acid 1,2,3-trimethoxy-9-methylsul...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of tubulin polymerization with preincubation for 15 minutes at 37 degree Centigrade prior to addition of the GTP required for polymerizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetTubulin alpha-1A chain(Pig)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50047704(2-Fluoro-benzoic acid 1,2,3-trimethoxy-9-methylsul...)
Affinity DataIC50: 3.63E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50047704(2-Fluoro-benzoic acid 1,2,3-trimethoxy-9-methylsul...)
Affinity DataIC50: 3.80E+3nMAssay Description:Evaluated for the inhibition of tubulin polymerization without pre-incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed