BDBM50048291 6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-2-carboxylic acid::6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid::6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthoic acid::CHEMBL1180::O-Demethylated Adapalene

SMILES OC(=O)c1ccc2cc(ccc2c1)-c1ccc(O)c(c1)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=LDGIHZJOIQSHPB-UHFFFAOYSA-N

Data  3 KI  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048291   

TargetRetinoic acid receptor gamma(Human)
Cird Galderma

Curated by ChEMBL
LigandPNGBDBM50048291(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)
Affinity DataKi:  77nMAssay Description:Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetRetinoic acid receptor beta(Human)
Cird Galderma

Curated by ChEMBL
LigandPNGBDBM50048291(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)
Affinity DataKi:  2.48E+3nMAssay Description:Binding affinity to retinoic acid receptor beta using [3H]-CD 367 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor alpha(Human)
Cird Galderma

Curated by ChEMBL
LigandPNGBDBM50048291(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)
Affinity DataKi:  6.50E+3nMAssay Description:Binding affinity to retinoic acid receptor alpha using [3H]-CD 367 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor beta(Human)
Cird Galderma

Curated by ChEMBL
LigandPNGBDBM50048291(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)
Affinity DataEC50:  226nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARbeta (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRetinoic acid receptor gamma(Human)
Cird Galderma

Curated by ChEMBL
LigandPNGBDBM50048291(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)
Affinity DataEC50:  49nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARgamma (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetRetinoic acid receptor alpha(Human)
Cird Galderma

Curated by ChEMBL
LigandPNGBDBM50048291(6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4 DNA-binding domain-tagged RARalpha (unknown origin) ligand-binding domain expressed in human HG5LN cells incubated for 18 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed