BDBM50049021 5-(3-Chloro-4-fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-spiro[2.4]hept-5-ene::CHEMBL88286

SMILES CS(=O)(=O)c1ccc(cc1)C1=C(CC2(CC2)C1)c1ccc(F)c(Cl)c1

InChI Key InChIKey=OBDYUVYOLLAPQL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50049021   

TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049021(5-(3-Chloro-4-fluoro-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049021(5-(3-Chloro-4-fluoro-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50: 7.08nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049021(5-(3-Chloro-4-fluoro-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50: 6.01E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed