BDBM50050625 2-(2-Propoxy-phenyl)-3H-pyrimido[4,5-d]pyrimidin-4-one::CHEMBL42563

SMILES CCCOc1ccccc1-c1nc2ncncc2c(=O)[nH]1

InChI Key InChIKey=JSQKADIKWSKCGA-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50050625   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Laboratories Glaxo Wellcome Centre De Recherches

Curated by ChEMBL
LigandPNGBDBM50050625(2-(2-Propoxy-phenyl)-3H-pyrimido[4,5-d]pyrimidin-4...)
Affinity DataIC50: 300nMAssay Description:Inhibition of Phosphodiesterase 5 from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Rat)
Laboratories Glaxo Wellcome Centre De Recherches

Curated by ChEMBL
LigandPNGBDBM50050625(2-(2-Propoxy-phenyl)-3H-pyrimido[4,5-d]pyrimidin-4...)
Affinity DataEC50:  7.50E+3nMAssay Description:Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed