BDBM50051884 1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl]-3,5-dimethyl-1H-pyrazole::CHEMBL33661::Diphenylimidazole analogue

SMILES Cc1cc(C)n(CCCCCS(=O)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1

InChI Key InChIKey=POQMHHDKXWTFHB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50051884   

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  245nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit artery.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  75nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSterol O-acyltransferase 1(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholest...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSterol O-acyltransferase 1(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  85nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSterol O-acyltransferase 1(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  108nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from HEP G2 cells.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  122nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit intestine.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  370nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit adrenal.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  208nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit intestine.More data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  164nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from THP-1 cells.More data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  86nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rat liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051884(1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)
Affinity DataIC50:  75nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed