BDBM50051901 1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-pentyl]-3,5-dimethyl-1H-pyrazole::CHEMBL33780

SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1

InChI Key InChIKey=UUPITLNVYVCTFW-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50051901   

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  53nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicateMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  79nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit adrenalMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase in rat hepatic microsomes was measured by using AIV assayMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit artery.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholest...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSterol O-acyltransferase 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  44nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit liver.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  108nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit liver.More data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  80nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rabbit adrenal.More data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  45nMAssay Description:Concentration required for the inhibition of ACAT from rat gutMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  90nMAssay Description:Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell cultureMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  25nMAssay Description:Compound was evaluated for inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase in microsomes from rat liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  25nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from rat liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  62nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from cholesterol fed rabbit liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  119nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit arteryMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  69nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from human liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  35nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit gutMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  92nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset adrenalMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from pig liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  43nMAssay Description:Concentration required for the inhibition of rabbit arterial Acyl coenzyme A:cholesterol acyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  44nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset gutMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  40nMAssay Description:Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from rat liverMore data for this Ligand-Target Pair
In DepthDetails Article

TargetSterol O-acyltransferase 1(Chinese hamster)
TBA

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50:  12nMAssay Description:Concentration required for the inhibition of Cholesterol O-acyl transferase from hamster liverMore data for this Ligand-Target Pair
In DepthDetails Article