BDBM50054893 2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3-thiophen-2-yl-propionylamino)-3-(4-guanidino-phenyl)-propionylamino]-4-methyl-pentanoic acid (1-carbamoyl-4-guanidino-butyl)-amide::CHEMBL434696

SMILES [#6]-[#6](-[#6])-[#6]-[#6](-[#7]-[#6](=O)-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#6]-c1cccs1)-[#7](-[#6](-[#6])=O)-[#6](=O)-[#6]=[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7])-[#6](-[#7])=O

InChI Key InChIKey=UZAWTWNALIYPPR-IQYBQOEQSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50054893   

TargetProteinase-activated receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50054893(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Affinity DataIC50:  42nMAssay Description:Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProteinase-activated receptor 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50054893(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Affinity DataIC50:  3.31E+3nMAssay Description:Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed