BDBM50056241 6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL423560

SMILES COc1cc2CCN(Cc3cnc4nc(N)nc(N)c4c3C)c2cc1OC

InChI Key InChIKey=BZNVHZNLTGLZKQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056241   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056241(6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-m...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Dihydrofolate Reductase of Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056241(6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-m...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Dihydrofolate Reductase of Rat Liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056241(6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-m...)
Affinity DataIC50:  410nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056241(6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-m...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056241(6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-m...)
Affinity DataIC50:  230nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056241(6-(5,6-Dimethoxy-2,3-dihydro-indol-1-ylmethyl)-5-m...)
Affinity DataIC50:  410nMAssay Description:Inhibition of Dihydrofolate Reductase of Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed