BDBM50056244 6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL147886

SMILES COc1cc2CCN(Cc3cnc4nc(N)nc(N)c4c3C)Cc2cc1OC

InChI Key InChIKey=MMSIAUDANZHRRG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50056244   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056244(6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056244(6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Dihydrofolate Reductase of Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056244(6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50: 130nMAssay Description:Inhibition of Dihydrofolate Reductase of Rat Liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056244(6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50: 130nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056244(6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50: 850nMAssay Description:Inhibition of Dihydrofolate Reductase of Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50056244(6-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50: 850nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed