BDBM50058210 CHEMBL445098::[9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; compound with methanesulfonic acid

SMILES CNc1ncnc2n(Cc3ccccc3F)cnc12

InChI Key InChIKey=MZABAGHILOTTOD-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50058210   

LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to PDE4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of PDE5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataKi:  3.50E+4nMAssay Description:Binding affinity to PDE3B (unknown origin) using [3H]cAMP as substrate assessed as inhibition constant incubated for 1 hrs by surface plasmon resonan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
Upr 421 Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]CHA from Adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataKi:  1.22E+5nMAssay Description:Inhibition of full-length recombinant human PDE2A using [3H]-cGMP as substrate incubated for 10 mins by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50058210([9-(2-Fluoro-benzyl)-9H-purin-6-yl]-methyl-amine; ...)
Affinity DataKi:  1.22E+5nMAssay Description:Inhibition of Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed