BDBM50058625 CHEMBL418475::N-hydroxy-N-({5-[(E)-2-thien-2-ylvinyl]thien-2-yl}methyl)urea

SMILES NC(=O)N(O)Cc1ccc(\C=C\c2cccs2)s1

InChI Key InChIKey=CDOVRPFCBIJNHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50058625   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50058625(N-hydroxy-N-({5-[(E)-2-thien-2-ylvinyl]thien-2-yl}...)
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50058625(N-hydroxy-N-({5-[(E)-2-thien-2-ylvinyl]thien-2-yl}...)
Affinity DataIC50: 830nMAssay Description:Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed