BDBM50059307 CHEMBL3393439::US9156845, 1

SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12

InChI Key InChIKey=VNWKCLDQBNSJJO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50059307   

LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 using fluorescein-labeled LRRKtide peptide substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 13nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
US Patent

LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 36nMpH: 7.5Assay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
US Patent

LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 36nMAssay Description:Inhibition of GST-tagged truncated human recombinant LRRK2 G2019S mutant using fluorescein-labeled LRRKtide peptide substrate incubated for 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 50nMAssay Description:Inhibition of LRRK2 in human PBMCs by ActivX KiNativ methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 278nMAssay Description:Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 1.00E+3nMAssay Description:The STK3 kinase assay was performed in 5 μL reaction buffer containing 50 ng recombinant human STK3 protein (full length, SignalChem #S24-10G; Richmo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase 3(Human)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM50059307(CHEMBL3393439 | US9156845, 1 | US20250051337, Comp...)
Affinity DataIC50: 3.00E+3nMAssay Description:The STK3 kinase assay was performed in 5 μL reaction buffer containing 50 ng recombinant human STK3 protein (full length, SignalChem #S24-10G; Richmo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent