BDBM50063982 5-((2,5-dichlorophenylamino)methyl)furo[2,3-d]pyrimidine-2,4-diamine::5-[(2,5-Dichloro-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL277438

SMILES Nc1nc(N)c2c(CNc3cc(Cl)ccc3Cl)coc2n1

InChI Key InChIKey=OZYVFDXJXOPCJM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50063982   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063982(5-((2,5-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063982(5-((2,5-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063982(5-((2,5-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: 5.09E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from pneumocystis cariniiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063982(5-((2,5-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: 7.19E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50063982(5-((2,5-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: 7.19E+4nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed