BDBM50065057 1-(4-Fluoro-benzyl)-3-(6-methyl-2,4-bis-methylsulfanyl-pyridin-3-yl)-1-[3-(2H-pyrazol-3-yl)-benzyl]-urea::CHEMBL80763

SMILES CSc1cc(C)nc(SC)c1NC(=O)N(Cc1ccc(F)cc1)Cc1cccc(c1)-c1cc[nH]n1

InChI Key InChIKey=SRZBOWZVGHTYNN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50065057   

TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065057(1-(4-Fluoro-benzyl)-3-(6-methyl-2,4-bis-methylsulf...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity towards ACAT by the displacement of [1-14C]oleolyl-CoA from the small intestine of cholesterol-fed rabbitsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcyl-CoA:cholesterol acyltransferase(Rabbit)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065057(1-(4-Fluoro-benzyl)-3-(6-methyl-2,4-bis-methylsulf...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed