BDBM50068442 1,4-Bis-[2-(2-methoxy-phenyl)-ethyl]-piperazine::CHEMBL144393
SMILES COc1ccccc1CCN1CCN(CCc2ccccc2OC)CC1
InChI Key InChIKey=YHJWAFQSMFXGPG-UHFFFAOYSA-N
Data 6 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50068442
Affinity DataKi: 35nMAssay Description:Inhibition of VMAT2 in rat striatal homogenate assessed as reduction in [3H]DA uptake after 8 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 145nMAssay Description:Binding affinity was tested against sigma-1 receptor in guinea brain membranes.More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Kentucky
Curated by ChEMBL
University of Kentucky
Curated by ChEMBL
Affinity DataKi: 1.02E+3nMAssay Description:Inhibition of [3H]dofetilide binding to human ERG expressed in HEK293 cell membranes after 60 mins by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.17E+3nMAssay Description:Inhibition of [3H]DTBZ binding to VMAT2 in rat whole brain homogenate (excluding cerebellum) after 30 mins by liquid scintillation spectrometric anal...More data for this Ligand-Target Pair
Affinity DataKi: 1.58E+3nMAssay Description:Inhibition of SERT in rat striatal synaptosomes assessed as reduction in [3H]5-HT uptake preincubated for 5 mins followed by [3H]5-HT addition measur...More data for this Ligand-Target Pair
Affinity DataKi: 1.44E+4nMAssay Description:Inhibition of DAT in rat striatal synaptosomes assessed as reduction in [3H]DA uptake preincubated for 5 mins followed by [3H]DA addition measured af...More data for this Ligand-Target Pair