BDBM50069795 CHEMBL3407559

SMILES COc1cc(ccc1NC(=O)C[C@@]1(C)C[C@@H]([C@H](N([C@H](CS(=O)(=O)C(C)(C)C)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1)C(O)=O

InChI Key InChIKey=WAIDWBATMDUNPX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50069795   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50069795(CHEMBL3407559)
Affinity DataIC50: 0.180nMAssay Description:Binding affinity to human GST-thrombin-tagged MDM2 ( 1 to 188 aa) assessed as inhibition of interaction with human p53 preincubated with compound for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMed