BDBM50069846 3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine::CHEMBL312964

SMILES CCCCc1cncc(OC[C@@H]2CCCN2C)c1

InChI Key InChIKey=KJKJEMGOLPUHLS-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50069846   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H](-)-cytisine in whole rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataIC50: 640nMAssay Description:Inhibition of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory concentration to antagonise cation efflux in nAChR subtype human alpha3betaX, expressed in IMR-32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50069846(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)
Affinity DataEC50: >1.00E+6nMAssay Description:Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed