BDBM50070288 2-(3,4-Difluoro-benzyl)-3-hydroxy-4-(propane-2-sulfonyl)-2H-isoquinolin-1-one::CHEMBL275376

SMILES CC(C)S(=O)(=O)c1c(O)n(Cc2ccc(F)c(F)c2)c(=O)c2ccccc12

InChI Key InChIKey=QRZBUZGQIBTFCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50070288   

TargetProstaglandin G/H synthase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50070288(2-(3,4-Difluoro-benzyl)-3-hydroxy-4-(propane-2-sul...)
Affinity DataIC50: 200nMAssay Description:Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50070288(2-(3,4-Difluoro-benzyl)-3-hydroxy-4-(propane-2-sul...)
Affinity DataIC50: 570nMAssay Description:Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed