BDBM50072707 5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL8639

SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4OC(CC=C)c3c12

InChI Key InChIKey=BQFHIOXHOTZDCT-UHFFFAOYSA-N

Data  6 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50072707   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataEC50:  9nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi:  34nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataEC50: >300nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataEC50:  350nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataEC50:  561nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi:  889nMAssay Description:Displacement of Dexamethasone from human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of DHT from human androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072707(5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity towards testosterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed