BDBM50073118 CHEMBL319237::[(S)-8-((S)-2-Mercapto-3-phenyl-propionylamino)-7-oxo-6-aza-spiro[4.6]undec-6-yl]-acetic acid

SMILES OC(=O)CN1C(=O)[C@H](CCCC11CCCC1)NC(=O)[C@@H](S)Cc1ccccc1

InChI Key InChIKey=QPROPYDVVDTNLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50073118   

TargetAngiotensin-converting enzyme(Rabbit)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50073118([(S)-8-((S)-2-Mercapto-3-phenyl-propionylamino)-7-...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzyme (ACE) isolated from rabbit lung extract using hippuryl-L-histidyl-L-leucine (HHL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin(Rat)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50073118([(S)-8-((S)-2-Mercapto-3-phenyl-propionylamino)-7-...)
Affinity DataIC50: 426nMAssay Description:In vitro inhibitory activity against purified rat kidney neutral endopeptidase (NEP) using a fluorometric assay with dansyl-Gly-Phe-Arg as the substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed