BDBM50073554 CHEMBL3408940::US10358436, Example A110::US9907800, Example A110

SMILES CN1CCN(c2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)N(C)c5ccccc56)ccc34)cn2)CC1

InChI Key InChIKey=JZIZUMLXHJPWJH-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50073554   

LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using DBF as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073554BDBM50073554(CHEMBL3408940 | US9907800, Example A110 | US103584...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed