BDBM50073583 CHEMBL3408943::US9907800, Example A106

SMILES O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CC[C@@H](F)C4)cc3)n[nH]c2c1

InChI Key InChIKey=HYQVDRMLTQMPMN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50073583   

LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP2C9 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073583BDBM50073583(CHEMBL3408943 | US9907800, Example A106)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using DBF as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed