BDBM50074156 C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-yl]-ethyl}-1H-indol-5-yl)-N-methyl-methanesulfonamide::CHEMBL161780

SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN3CC[C@@H](CNCc4ccccc4)C3)c2c1

InChI Key InChIKey=MGCUTECDFDAQCK-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074156   

Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataIC50: 1.10nMAssay Description:Affinity of compound towards 5-hydroxytryptamine 1D receptor was evaluated using radioligand binding techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataEC50:  3.5nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataIC50: 41nMAssay Description:Affinity of compound towards 5-hydroxytryptamine 1A receptor was evaluated using radioligand binding techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataIC50: 62nMAssay Description:Affinity of compound towards 5-hydroxytryptamine 1B receptor was evaluated using radioligand binding techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataIC50: 62nMAssay Description:Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074156(C-(3-{2-[(S)-3-(Benzylamino-methyl)-pyrrolidin-1-y...)
Affinity DataIC50: 5.80E+3nMAssay Description:Affinity of compound towards human 5-hydroxytryptamine 2A receptor was evaluated using radioligand binding techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed