BDBM50074501 Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine::Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine(antalarmin)::CHEMBL296641
SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
InChI Key InChIKey=IXPROWGEHNVJOY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50074501
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals
Curated by ChEMBL
Dupont Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 0.840nMAssay Description:Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cellsMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brainMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellumMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals
Curated by ChEMBL
Dupont Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cellsMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals
Curated by ChEMBL
Dupont Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cellsMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals
Curated by ChEMBL
Dupont Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 32nMAssay Description:Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assayMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals
Curated by ChEMBL
Dupont Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Displacement of [125I]Tyr0sauvagine from human CRF1 receptor expressed in HEK293 cell membrane after 120 mins by gamma scintillation counting analysi...More data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals
Curated by ChEMBL
Dupont Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Displacement of [125I]-Tyr0-sauvagine from human CRFR1 expressed in HEK293 cell membrane homogenates after 120 mins by gamma counting methodMore data for this Ligand-Target Pair