BDBM50074723 6-Benzyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL6970

SMILES Nc1nc(N)c2CC(Cc3ccccc3)CCc2n1

InChI Key InChIKey=JHAGNGFBQHOFEL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50074723   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074723(6-Benzyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamin...)
Affinity DataIC50: 32nMAssay Description:The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074723(6-Benzyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamin...)
Affinity DataIC50: 180nMAssay Description:The ability to inhibit rat liver Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074723(6-Benzyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamin...)
Affinity DataIC50: 290nMAssay Description:The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed