BDBM50074728 6-(thiophen-3-ylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diamine::6-Thiophen-3-ylmethyl-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL7586

SMILES Nc1nc(N)c2CC(Cc3ccsc3)CCc2n1

InChI Key InChIKey=WAFODCNMOVYJTA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50074728   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074728(6-(thiophen-3-ylmethyl)-5,6,7,8-tetrahydroquinazol...)
Affinity DataIC50: 49nMAssay Description:The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074728(6-(thiophen-3-ylmethyl)-5,6,7,8-tetrahydroquinazol...)
Affinity DataIC50: 130nMAssay Description:The ability to inhibit rat liver Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50074728(6-(thiophen-3-ylmethyl)-5,6,7,8-tetrahydroquinazol...)
Affinity DataIC50: 1.70E+3nMAssay Description:The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed