BDBM50074889 1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-pyridin-2-yl]-1H-quinolin-2-one::CHEMBL12383

SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4ccc3=O)c2cc1OC

InChI Key InChIKey=IQKXFSXPCZEULC-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50074889   

LigandPNGBDBM50074889(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074889(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50:  330nMAssay Description:In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074889(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Phosphodiesterase 5 of guinea pig lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50074889(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50:  2.80nMAssay Description:In vitro inhibition of Phosphodiesterase 4 from guinea pig lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50074889(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Phosphodiesterase 1 of guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed